Carbidopa monohydrate
Carbidopa monohydrate
CAS: 38821-49-7
Molecular Formula: C10H16N2O5
Carbidopa monohydrate - Names and Identifiers
| Name | Carbidopa monohydrate |
| Synonyms | CARBIDOPA CARBIDOPA HYDRATE CARBIDOPA MONOHYDRATE Carbidopa monohydrate Carbidopa for system suitability (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropionic Acid (+)-2-(3,4-dihydroxybenzyl)-2-hydrazinopropionic acid monohydrate (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropionic acid monohydrate Carbidopa SynonyMs (+)-2-(3,4-Dihydroxybenzyl)-2-hydrazinopropionic acid Monohydrate |
| CAS | 38821-49-7 |
| EINECS | 642-905-9 |
| InChI | InChI=1/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2 |
Carbidopa monohydrate - Physico-chemical Properties
| Molecular Formula | C10H16N2O5 |
| Molar Mass | 244.24 |
| Boling Point | 528.7°C at 760 mmHg |
| Flash Point | 273.5°C |
| Solubility | Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of mineral acids. |
| Vapor Presure | 5.27E-12mmHg at 25°C |
| Appearance | neat |
| Color | White to Off-White |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Use | Used as a deacetylase inhibitor |
| In vitro study | Carbidopa ((S)-(-)-Carbidopa) monohydrate exhibits activities similar to that described for other AhR ligands in BχPC3 and Capan-2 cells, namely the induction of CYP1A1 and CYP1A2, which are inhibited by AhR antagonists such as CH223191. Carbidopa, a aromatic-L-amino acid decarboxylase inhibitor, is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. Carbidopa is lethal (IC 50 =29 μM). |
| In vivo study | Carbidopa monohydrate also induces nuclear uptake of the AhR, and in vivo studies show that carbidopa at a dose of 1 mg/mouse significantly inhibits tumor growth in athymic nude mice bearing BχPC3 cells as xenografts. |
Carbidopa monohydrate - Risk and Safety
| WGK Germany | 3 |
| RTECS | MW5300000 |
| HS Code | 2928002500 |
| Hazard Class | IRRITANT |
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